April 9, 2014

Scientist locate ‘control center’

A new study may have unlocked the key to understanding the physiological mechanism behind alcoholism. Conducted by researchers at the University of Utah and published last week in the journal  PLOS ONE,  the study looked at the effect of the lateral habenula — a part of the brain that's activated by bad experiences — on self-control and drinking patterns.

Scientists inactivated the lateral habenula regions of half of their rat subjects (using an electric shock), then gave all of the rodents access to an alcohol solution on an intermittent basis over six weeks.

They found that over time, the rats with inactivated lateral habenulae not only drank more rapidly but also more heavily than the rats in the control group. Despite the unpleasant physical effects they experienced as they began drinking more heavily, these rats continued to consume more and more alcohol, while the control group learned from their overindulgent experiences and curtailed their behaviors. This suggests that inactivating the lateral habenulae interfered with the normal responses that occur after overconsumption.

This area of the brain might regulate how badly a person perceives the physical consequences of drinking, so inactivating it could prevent your body from feeling the averse effects of overindulging. Or, it might impair learning — so it could be that the rats were less able to learn from the negative outcomes of their drinking.


 

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